TLDR: The American College of Cardiology (ACC) has partnered with OpenEvidence, an AI-driven clinical decision support platform, to integrate generative artificial intelligence into cardiovascular care. This collaboration aims to enhance access to evidence-based medical content, streamline clinical decision-making, and improve patient outcomes by providing clinicians with timely and accurate information at the point of care.
WASHINGTON – November 7, 2025 – The American College of Cardiology (ACC) and OpenEvidence have announced a strategic partnership set to transform cardiovascular care through the responsible integration of artificial intelligence (AI). This collaboration will leverage OpenEvidence’s advanced generative AI technology with ACC’s extensive leadership in cardiovascular science and education to deliver cutting-edge, evidence-based care directly to clinicians.
The primary objective of this alliance is to accelerate the translation of cardiovascular clinical guidance and research into practical clinical implementation. By doing so, clinicians will gain seamless access to the most current, relevant, and actionable medical evidence, thereby supporting informed shared decision-making with their patients.
Cathleen C. Gates, CEO of the ACC, emphasized the organization’s commitment: “At the American College of Cardiology, our mission is to transform cardiovascular care and improve heart care for all because patients deserve care that’s not only informed by the latest scientific evidence, but also delivered with confidence and compassion.” She added, “Our collaboration with OpenEvidence will allow us to responsibly integrate AI into clinical workflows, ensuring that patients benefit from timely, evidence-based care without compromising safety, transparency or the trusted judgment of their clinicians.”
OpenEvidence, recognized as the fastest-growing clinical decision support platform in the United States and the most widely used medical search engine among U.S. clinicians, brings its powerful AI capabilities to the forefront. Daniel Nadler, PhD, CEO of OpenEvidence, highlighted the critical role of cardiovascular knowledge: “When we look at what clinicians are searching on OpenEvidence, the heart is everywhere: central to pathophysiology, and central to clinical decision-making.” He further stated, “From family physicians and emergency doctors to intensivists and trauma surgeons, clinicians across every specialty rely on the work of the ACC to guide evidence-based care. We’re thrilled to partner with the organization that defines the foundation for cardiovascular practice, bringing their trusted expertise to the point of care through responsible, generative AI.”
The partnership will facilitate several key initiatives, including the creation of supplemental materials to support evidence-based treatment and care delivery. An expert work group comprising cardiovascular clinicians will be convened to identify high-impact areas, frequently asked questions, and knowledge gaps based on real-world clinical inquiries. This group will also explore opportunities to enhance clinical guidance development and create new educational materials optimized for generative AI in practice.
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Further expanding their joint efforts, an ACC/OpenEvidence AI Resource Center and a dedicated podcast series are in development, designed to explore the evolving landscape of AI technologies in cardiovascular medicine. Additionally, the ACC Annual Scientific Session will feature an ACC Future Hub, where attendees will have frontline access to practice-changing technologies aimed at optimizing patient care and outcomes.
