TLDR: At HLTH 2025, Wolters Kluwer Health unveiled its UpToDate Expert AI, a generative AI-powered clinical decision support tool designed to provide responsible, evidence-based insights at the point of care. The company also introduced UpToDate Pro Plus and the UpToDate Connect API, reinforcing its commitment to integrating trusted clinical intelligence seamlessly into healthcare workflows.
WALTHAM, Mass. – October 17, 2025 – Wolters Kluwer Health made a significant impact at HLTH 2025, showcasing its innovative UpToDate Expert AI and a suite of workflow solutions aimed at transforming clinical decision support and care delivery. The company emphasized its dedication to responsible, evidence-based artificial intelligence, designed to empower healthcare organizations and clinicians with trusted, actionable insights.
The centerpiece of Wolters Kluwer’s presentation was the recently launched UpToDate Expert AI. This generative AI (GenAI)-powered tool is built upon Wolters Kluwer’s extensive peer-reviewed content library, drawing from over 30 years of research authored by more than 7,600 expert contributors. Unlike general-purpose chatbots, UpToDate Expert AI is engineered to provide rapid answers to complex clinical questions while explicitly surfacing its sources, assumptions, and step-by-step reasoning, thereby mitigating the risk of ‘hallucinations’ and ensuring clinical credibility.
Greg Samios, CEO of Wolters Kluwer Health, highlighted the critical need for reliable AI in healthcare. “Our customers have made it clear that GenAI at the point-of-care must be grounded in clinical credibility and expert guidance—not just fast answers,” Samios stated. “UpToDate Expert AI is already being adopted by clinicians across 70% of our largest enterprise health systems, signaling strong momentum and trust in our approach. Our mission remains unchanged: to deliver reliable information to the right person at the right time, with transparency, trust, and seamless integration into clinical workflows.”
In addition to the enterprise solution, Wolters Kluwer Health also announced the launch of UpToDate Pro Plus, which integrates Expert AI into UpToDate Pro, making responsible GenAI accessible to students, residents, and group practice clinicians. This expansion aims to accelerate informed decision-making and streamline clinical workflows across various levels of medical practice.
Further enhancing workflow efficiency, Wolters Kluwer debuted UpToDate Connect, a powerful API solution. This allows digital health developers to embed clinical intelligence directly into existing tools that clinicians use daily, reducing friction and ensuring that appropriate information is delivered precisely when and where it’s needed. This initiative aligns with Wolters Kluwer’s broader vision for care delivery, focusing on enabling fast, safe clinical decisions, improving care efficiencies, unifying clinician and patient journeys, and optimizing resource use for a strong return on investment.
The impact of UpToDate Expert AI has already garnered external recognition. A recent report from leading research and advisory firm Outsell, Inc., noted that the tool “raises the bar for clinical decision support, delivering trusted, transparent AI in real workflows,” further stating that “this offer is not a generic chatbot, but a tool that draws strictly from UpToDate’s peer-reviewed, evidence-based content. Every answer stays grounded without hallucination and shows reasoning, assumptions, and citations.”
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Attendees at HLTH 2025 had the opportunity to witness live demonstrations of UpToDate Expert AI at booth #3218. Furthermore, a dedicated session on ‘Generative AI and Care Delivery’ was scheduled for Tuesday, October 21, at 3:30 p.m. PDT in the HLTH AI Zone (Theater C), featuring Amanda Heidemann, MD, and Holden K. Groves, MD, who discussed the balance of reliability, speed, and privacy when implementing GenAI in healthcare.
